Showing posts with label Cardiac Markers. Show all posts
Showing posts with label Cardiac Markers. Show all posts

Jan 18, 2013

Tips to keep your Brain Fit....


 Exercise—Physically active people can reduce their risk of dementia by 30 to 40 percent. Weight Training—Studies have shown that resistance training can increase brain growth factors, which protect nerve cells.

 Learn Something New—Challenging your brain does in fact increase the number of brain cells and the connections between them. 

Relax—Regular, chronic stress can lead to impaired memory because it floods your brain with cortisol.

 Go Greek—Eating a diet rich in fish, vegetables, fruits, nuts and beans (otherwise known as a Mediterranean diet) has been shown to reduce Alzheimer’s risk by 34 to 48 percent in Columbia University studies. 

Spice It Up— Many herbs and spices are high in antioxidants, which may help build brainpower. Set a Goal—Having a clear path or mission in life can reduce your chances of developing Alzheimer's disease. 

Socialize—People who need people, well, they may be protected against dementia because social interaction provides emotional and mental stimulation. 

Reduce Other Risk Factors—Many chronic health conditions, such as diabetes, obesity and hypertension, have been linked with an increased risk of dementia. 

Take a Vitamin—Declines in digestive acids or as a result of medication interference can inhibit your absorption of some of the nutrients you need from foods, particularly B12, which can affect your brain’s vitality. Incorporate some or all of these tips into your daily life and you will be doing your part to keep your mind sharp and your brain active long into your golden years.....

Sep 11, 2011

Diabetes, Heart Disease, and Stroke....

Diabetes and heart health

Diabetes raises the chances of developing heart problems... eating well and getting or staying active. Even if you have had a heart attack already, you can do a lot more than just take medicines your doctor prescribes.

What causes heart disease?


Atherosclerosis is when, over time, fat deposits from cholesterol build up on the walls of your arteries. As the fat builds up, less blood is flows through. If the blood to your heart is blocked enough, you have a heart attack. If these fat deposits break loose, the result is a stroke. This is why doctors focus on reducing cholesterol.
Diabetes is also more likely to cause heart problems due to damage from high glucose levels and high blood pressure.

Managing A1c levels

A1c is a measure of your blood sugar control over a period of time....daily testing for glucose levels will help manage how well you feel. Regular A1c tests help you know what steps you have to take to keep your blood sugar under control to protect your heart.

Managing blood pressure

 High blood pressure can cause heart and kidney disease. Some people can reduce it with changes in diet or physical activity. Others require medicines. Your doctor or doctors will help you make the best decision for your specific situation.

Managing cholesterol

 This chart shows you what most doctors agree are good measures of the scores you get.
Normal less than 150 mg/dL
Borderline High 150-199 mg/dL
High 200-499 mg/dL
Very High 500 mg/dL


What are the risk factors for heart disease and stroke in people with diabetes?

Diabetes itself is a risk factor for heart disease and stroke. Also, many people with diabetes have other conditions that increase their chance of developing heart disease and stroke. These conditions are called risk factors. One risk factor for heart disease and stroke is having a family history of heart disease. If one or more members of your family had a heart attack at an early age (before age 55 for men or 65 for women), you may be at increased risk.
You can't change whether heart disease runs in your family, but you can take steps to control the other risk factors for heart disease listed here:
  • Having central obesity. Central obesity means carrying extra weight around the waist, as opposed to the hips. A waist measurement of more than 40 inches for men and more than 35 inches for women means you have central obesity. Your risk of heart disease is higher because abdominal fat can increase the production of LDL (bad) cholesterol, the type of blood fat that can be deposited on the inside of blood vessel walls.


  • Having abnormal blood fat (cholesterol) levels.
    - LDL cholesterol can build up inside your blood vessels, leading to narrowing and hardening of your arteries-the blood vessels that carry blood from the heart to the rest of the body. Arteries can then become blocked. Therefore, high levels of LDL cholesterol raise your risk of getting heart disease.

    - Triglycerides are another type of blood fat that can raise your risk of heart disease when the levels are high.

    - HDL (good) cholesterol removes deposits from inside your blood vessels and takes them to the liver for removal. Low levels of HDL cholesterol increase your risk for heart disease.


  • Having high blood pressure. If you have high blood pressure, also called hypertension, your heart must work harder to pump blood. High blood pressure can strain the heart, damage blood vessels, and increase your risk of heart attack, stroke, eye problems, and kidney problems.


  • Smoking. Smoking doubles your risk of getting heart disease. Stopping smoking is especially important for people with diabetes because both smoking and diabetes narrow blood vessels. Smoking also increases the risk of other long-term complications, such as eye problems. In addition, smoking can damage the blood vessels in your legs and increase the risk of amputation.


What is metabolic syndrome and how is it linked to heart disease?

Metabolic syndrome is a grouping of traits and medical conditions that puts people at risk for both heart disease and type 2 diabetes. It is defined by the National Cholesterol Education Program as having any three of the following five traits and medical conditions:
Traits and Medical Conditions Definition
Elevated waist circumference Waist measurement of
  • 40 inches or more in men
  • 35 inches or more in women
Elevated levels of triglycerides
  • 150 mg/dL or higher
    or
  • Taking medication for elevated triglyceride levels
Low levels of HDL (good) cholesterol
  • Below 40 mg/dL in men
  • Below 50 mg/dL in women
    or
    Taking medication for low HDL cholesterol levels
Elevated blood pressure levels
  • 130 mm Hg or higher for systolic blood pressure or
  • 85 mm Hg or higher for diastolic blood pressure
    or
    Taking medication for elevated blood pressure levels
Elevated fasting blood glucose levels
  • 100 mg/dL or higher
    or
  • Taking medication for elevated blood glucose levels
Source: Grundy SM, et al. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735-2752.
Note: Other definitions of similar conditions have been developed by the American Association of Clinical Endocrinologists, the International Diabetes Federation, and the World Health Organization.
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What can I do to prevent or delay heart disease and stroke?

Even if you are at high risk for heart disease and stroke, you can help keep your heart and blood vessels healthy. You can do so by taking the following steps:

  • Make sure that your diet is "heart-healthy." Meet with a registered dietitian to plan a diet that meets these goals:
    • Include at least 14 grams of fiber daily for every 1,000 calories consumed. Foods high in fiber may help lower blood cholesterol. Oat bran, oatmeal, whole-grain breads and cereals, dried beans and peas (such as kidney beans, pinto beans, and black-eyed peas), fruits, and vegetables are all good sources of fiber. Increase the amount of fiber in your diet gradually to avoid digestive problems.
    • Cut down on saturated fat. It raises your blood cholesterol level. Saturated fat is found in meats, poultry skin, butter, dairy products with fat, shortening, lard, and tropical oils such as palm and coconut oil. Your dietitian can figure out how many grams of saturated fat should be your daily maximum amount.
    • Keep the cholesterol in your diet to less than 300 milligrams a day. Cholesterol is found in meat, dairy products, and eggs.
    • Keep the amount of trans fat in your diet to a minimum. It's a type of fat in foods that raises blood cholesterol. Limit your intake of crackers, cookies, snack foods, commercially prepared baked goods, cake mixes, microwave popcorn, fried foods, salad dressings, and other foods made with partially hydrogenated oil. In addition, some kinds of vegetable shortening and margarines have trans fat. Check for trans fat in the Nutrition Facts section on the food package.

  • Make physical activity part of your routine. Aim for at least 30 minutes of exercise most days of the week. Think of ways to increase physical activity, such as taking the stairs instead of the elevator. If you haven't been physically active recently, see your doctor for a checkup before you start an exercise program.
  • Reach and maintain a healthy body weight. If you are overweight, try to be physically active for at least 30 minutes a day, most days of the week. Consult a registered dietitian for help in planning meals and lowering the fat and calorie content of your diet to reach and maintain a healthy weight. Aim for a loss of no more than 1 to 2 pounds a week.
  • If you smoke, quit. Your doctor can help you find ways to quit smoking.

  •  
  • Ask your doctor whether you should take aspirin. Studies have shown that taking a low dose of aspirin every day can help reduce the risk of heart disease and stroke. However, aspirin is not safe for everyone. Your doctor can tell you whether taking aspirin is right for you and exactly how much to take.
  • Get prompt treatment for transient ischemic attacks (TIAs). Early treatment for TIAs, sometimes called mini-strokes, may help prevent or delay a future stroke. Signs of a TIA are sudden weakness, loss of balance, numbness, confusion, blindness in one or both eyes, double vision, difficulty speaking, or a severe headache.


How will I know whether my diabetes treatment is working?

You can keep track of the ABCs of diabetes to make sure your treatment is working. Talk with your health care provider about the best targets for you.
A stands for A1C (a test that measures blood glucose control). Have an A1C test at least twice a year. It shows your average blood glucose level over the past 3 months. Talk with your doctor about whether you should check your blood glucose at home and how to do it.
A1C target
Below 7 percent


Blood glucose targets
Before meals 90 to 130 mg/dL
1 to 2 hours after the start of a meal Less than 180 mg/dL
B is for blood pressure. Have it checked at every office visit.
Blood pressure target
Below 130/80 mm Hg
C is for cholesterol. Have it checked at least once a year.
Blood fat (cholesterol) targets
LDL (bad) cholesterol Under 100 mg/dL
Triglycerides Under 150 mg/dL
HDL (good) cholesterol For men: above 40 mg/dL
For women: above 50 mg/dL
Control of the ABCs of diabetes can reduce your risk for heart disease and stroke. changes in diet, activity, and medications can help reach  goals.


What types of heart and blood vessel disease occur in people with diabetes?

Two major types of heart and blood vessel disease, also called cardiovascular disease, are common in people with diabetes: coronary artery disease (CAD) and cerebral vascular disease. People with diabetes are also at risk for heart failure. Narrowing or blockage of the blood vessels in the legs, a condition called peripheral arterial disease, can also occur in people with diabetes.

Coronary Artery Disease

Coronary artery disease, also called ischemic heart disease, is caused by a hardening or thickening of the walls of the blood vessels that go to your heart. Your blood supplies oxygen and other materials your heart needs for normal functioning. If the blood vessels to your heart become narrowed or blocked by fatty deposits, the blood supply is reduced or cut off, resulting in a heart attack.

Cerebral Vascular Disease

Cerebral vascular disease affects blood flow to the brain, leading to strokes and TIAs. It is caused by narrowing, blocking, or hardening of the blood vessels that go to the brain or by high blood pressure.

Stroke

A stroke results when the blood supply to the brain is suddenly cut off, which can occur when a blood vessel in the brain or neck is blocked or bursts. Brain cells are then deprived of oxygen and die. A stroke can result in problems with speech or vision or can cause weakness or paralysis. Most strokes are caused by fatty deposits or blood clots-jelly-like clumps of blood cells-that narrow or block one of the blood vessels in the brain or neck. A blood clot may stay where it formed or can travel within the body. People with diabetes are at increased risk for strokes caused by blood clots.
A stroke may also be caused by a bleeding blood vessel in the brain. Called an aneurysm, a break in a blood vessel can occur as a result of high blood pressure or a weak spot in a blood vessel wall.

TIAs

TIAs are caused by a temporary blockage of a blood vessel to the brain. This blockage leads to a brief, sudden change in brain function, such as temporary numbness or weakness on one side of the body. Sudden changes in brain function also can lead to loss of balance, confusion, blindness in one or both eyes, double vision, difficulty speaking, or a severe headache. However, most symptoms disappear quickly and permanent damage is unlikely. If symptoms do not resolve in a few minutes, rather than a TIA, the event could be a stroke. The occurrence of a TIA means that a person is at risk for a stroke sometime in the future.

Heart Failure

Heart failure is a chronic condition in which the heart cannot pump blood properly-it does not mean that the heart suddenly stops working. Heart failure develops over a period of years, and symptoms can get worse over time. People with diabetes have at least twice the risk of heart failure as other people. One type of heart failure is congestive heart failure, in which fluid builds up inside body tissues. If the buildup is in the lungs, breathing becomes difficult.

Blockage of the blood vessels and high blood glucose levels also can damage heart muscle and cause irregular heart beats. People with damage to heart muscle, a condition called cardiomyopathy, may have no symptoms in the early stages, but later they may experience weakness, shortness of breath, a severe cough, fatigue, and swelling of the legs and feet. Diabetes can also interfere with pain signals normally carried by the nerves, explaining why a person with diabetes may not experience the typical warning signs of a heart attack.

Peripheral Arterial Disease

Another condition related to heart disease and common in people with diabetes is peripheral arterial disease (PAD). With this condition, the blood vessels in the legs are narrowed or blocked by fatty deposits, decreasing blood flow to the legs and feet. PAD increases the chances of a heart attack or stroke occurring. Poor circulation in the legs and feet also raises the risk of amputation. Sometimes people with PAD develop pain in the calf or other parts of the leg when walking, which is relieved by resting for a few minutes.
 

How will I know whether I have heart disease?

One sign of heart disease is angina, the pain that occurs when a blood vessel to the heart is narrowed and the blood supply is reduced. You may feel pain or discomfort in your chest, shoulders, arms, jaw, or back, especially when you exercise. The pain may go away when you rest or take angina medicine. Angina does not cause permanent damage to the heart muscle, but if you have angina, your chance of having a heart attack increases.
A heart attack occurs when a blood vessel to the heart becomes blocked. With blockage, not enough blood can reach that part of the heart muscle and permanent damage results. During a heart attack, you may have
  • chest pain or discomfort
  • pain or discomfort in your arms, back, jaw, neck, or stomach
  • shortness of breath
  • sweating
  • nausea
  • light-headedness
Symptoms may come and go. However, in some people, particularly those with diabetes, symptoms may be mild or absent due to a condition in which the heart rate stays at the same level during exercise, inactivity, stress, or sleep. Also, nerve damage caused by diabetes may result in lack of pain during a heart attack.
Women may not have chest pain but may be more likely to have shortness of breath, nausea, or back and jaw pain. If you have symptoms of a heart attack, call 911 right away. Treatment is most effective if given within an hour of a heart attack. Early treatment can prevent permanent damage to the heart.
Your doctor should check your risk for heart disease and stroke at least once a year by checking your cholesterol and blood pressure levels and asking whether you smoke or have a family history of premature heart disease. The doctor can also check your urine for protein, another risk factor for heart disease. If you are at high risk or have symptoms of heart disease, you may need to undergo further testing.


What are the treatment options for heart disease?

Treatment for heart disease includes meal planning to ensure a heart-healthy diet and physical activity. In addition, you may need medications to treat heart damage or to lower your blood glucose, blood pressure, and cholesterol. If you are not already taking a low dose of aspirin every day, your doctor may suggest it. You also may need surgery or some other medical procedure.
For additional information about heart and blood vessel disease, high blood pressure, and high cholesterol, call the National Heart, Lung, and Blood Institute Health Information Center at 301-592-8573 or see www.nhlbi.nih.gov on the Internet.


How will I know whether I have had a stroke?

The following signs may mean that you have had a stroke:
  • sudden weakness or numbness of your face, arm, or leg on one side of your body
  • sudden confusion, trouble talking, or trouble understanding
  • sudden dizziness, loss of balance, or trouble walking
  • sudden trouble seeing out of one or both eyes or sudden double vision
  • sudden severe headache
If you have any of these symptoms, call 911 right away. You can help prevent permanent damage by getting to a hospital within an hour of a stroke. If your doctor thinks you have had a stroke, you may have tests such as a neurological examination to check your nervous system, special scans, blood tests, ultrasound examinations, or x rays. You also may be given medication that dissolves blood clots.


What are the treatment options for stroke?

At the first sign of a stroke, you should get medical care right away. If blood vessels to your brain are blocked by blood clots, the doctor can give you a "clot-busting" drug. The drug must be given soon after a stroke to be effective. Subsequent treatment for stroke includes medications and physical therapy, as well as surgery to repair the damage. Meal planning and physical activity may be part of your ongoing care. In addition, you may need medications to lower your blood glucose, blood pressure, and cholesterol and to prevent blood clots.
For additional information about strokes, call the National Institute of Neurological Disorders and Stroke at 1-800-352-9424 or see www.ninds.nih.gov on the Internet.

  • If you have diabetes, you are at least twice as likely as other people to have heart disease or a stroke.
  • Controlling the ABCs of diabetes-A1C (blood glucose), blood pressure, and cholesterol-can cut your risk of heart disease and stroke.
  • Choosing foods wisely, being physically active, losing weight, quitting smoking, and taking medications (if needed) can all help lower your risk of heart disease and stroke.
  • If you have any warning signs of a heart attack or a stroke, get medical care immediately-don't delay. Early treatment of heart attack and stroke in a hospital emergency room can reduce damage to the heart and the brain.



Hope through Research

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is one of the National Institutes of Health (NIH) under the U.S. Department of Health and Human Services. The NIDDK conducts and supports research in diabetes, glucose metabolism, and related conditions. Several studies related to diabetes, heart disease, and stroke are under way.
  • The Look AHEAD (Action for Health in Diabetes) trial is studying whether strategies for weight loss in obese people with type 2 diabetes can improve health. This trial is also sponsored by other NIH Institutes and by the Centers for Disease Control and Prevention. For more information on the Look AHEAD trial, visit the website at www.niddk.nih.gov/patient/SHOW/lookahead.htm.
  • The EDIC (Epidemiology of Diabetes Interventions and Complications) study is examining the long-term effects of prior intensive versus conventional blood glucose control. It is a follow-up study of patients who took part more than a decade ago in the Diabetes Control and Complications Trial (DCCT), a major clinical study funded by the National Institutes of Health.
  • The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, sponsored by the National Heart, Lung, and Blood Institute, in partnership with NIDDK, is studying approaches to the medical care of people with type 2 diabetes who also have coronary artery disease. For more information on the BARI 2D trial, visit the website at www.bari2d.org Exit Disclaimer image or call the nearest research center (listed on the website).
  • The ACCORD (Action to Control Cardiovascular Risk in Diabetes) trial is studying three approaches to preventing major cardiovascular events in individuals with type 2 diabetes. For more information on the ACCORD trial, visit the website at www.accordtrial.org Exit Disclaimer image or call 1-888-342-2380.
  • The NIDDK and other components of the NIH will continue to fund research on the best ways to enhance health promotion, self-management, and risk reduction in people with diabetes.

Jul 14, 2011

Cardiac Nursing Tools and Books to Review.......

No Image
Publication Date: Jan 24, 2008
Availability: IN STOCK
Format: Chart
Edition: Second
ISBN/ISSN: 9780781773386
With updated images and text and improved design elements, this new edition chart provides an easy-to-understand overview of the important anatomical aspects of heart disease. The progression of heart disease in atherosclerosis is shown in three stages, each with an anatomical image of the surface or cross-section of the heart, a cross-section of an artery, and a cross-section of the heart wall. The stages show how a narrowed artery leads to ischemia; how a blocked artery leads to a myocardial infarction (heart attack); and show the recovery period with collateral blood supply.
The chart also shows heart disease in hypertension which can lead to hypertrophy and dilation of the left ventricle. Congestive heart failure, mitral valve prolapse, and the effects of aging on the heart are also illustrated and described.
For comparison, the chart also contains illustrations of normal heart anatomy, including anterior surface and cross-sections of the heart, the systems coronary arteries on the heart, and a cross-section of a normal coronary artery.






 

Practical Guide to Cardiac Pacing

No Image
Publication Date: Jan 30, 2007
Availability: IN STOCK
Format: Book
Edition: Sixth
ISBN/ISSN: 9780781788816 
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Anatomical Chart Company's Illustrated Pocket Anatomy: Anatomy of The Heart Study Guide

No Image
Publication Date: Sep 12, 2007
Availability: IN STOCK
Format: Folding Pocket Chart
Edition: Second
ISBN/ISSN: 9780781776813 - $10.00 u.s.d

Now in its Second Edition, this folding study guide takes the Anatomical Chart Company's most popular anatomical images and puts them in a durable, portable format that is perfect for the on-the-go student. Printed on a write-on, wipe-off laminated surface, this guide shows numbered anatomical structures and contains answers that can be concealed for easy self-testing and memorization. This edition features a fresh, clean design, updated content, and improved organizational features such as key subject headers at the top of each panel.


This quick reference includes:
  • Anterior (including cutaway view) and posterior views of heart
  • Coronary arteries and veins, including cross-sections of artery and vein
  • Thorax anatomy
  • Circulation
  • View and text explanation of the cardiac cycle including atrial systole, ventricular systole, and diastole
  • Explanation of blood pressure and lists of normal, low, and high BP levels
  • Illustrations and explanations of cardiac conduction, valves, and electrocardiogram (ECG)

Clinical Cardiac Electrophysiology

Techniques and Interpretations
No Image
Publication Date: Jun 17, 2008
Availability: IN STOCK
Format: Book
Edition: Fourth
ISBN/ISSN: 9780781777391


Jul 7, 2011

Cardiac Marckers for Acute MI

Cardiac markers are biomarkers measured to evaluate heart function. They are often discussed in the context of myocardial infarction, but other conditions can lead to an elevation in cardiac marker level.

Most of the early markers identified were enzymes, and as a result, the term "cardiac enzymes" is sometimes used. However, not all of the markers currently used are enzymes. For example, in formal usage, troponin would not be listed as a cardiac enzyme.


Types include:
Test Sensitivity and specificity Approximate peak Description



Troponin test The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. 12 hours Troponin is released during MI from the cytosolic pool of the myocytes. Its subsequent release is prolonged with degradation of actin and myosin filaments.
Differential diagnosis of troponin elevation includes acute infarction, severe pulmonary embolism causing acute right heart overload, heart failure, myocarditis. Troponins can also calculate infarct size but the peak must be measured in the 3rd day. released in 2–4 hours and persists for up to 7 days.



Creatine Kinase (CK-MB) test It is relatively specific when skeletal muscle damage is not present. 10–24 hours CK-MB resides in the cytosol and facilitates high energy phosphates into and out of mitochondria. It is distributed in a large number of tissues even in the skeletal muscle. Since it has a short duration, it cannot be used for late diagnosis of acute MI but can be used to suggest infarct extension if levels rise again. This is usually back to normal within 2–3 days.



Lactate dehydrogenase (LDH) LH is not as specific as troponin. 72 hours Lactate dehydrogenase catalyses the conversion of pyruvate to lactate. LDH-1 isozyme is normally found in the heart muscle and LDH-2 is found predominately in blood serum. A high LDH-1 level to LDH-2 suggest MI. LDH levels are also high in tissue breakdown or hemolysis. It can mean cancer, meningitis, encephalitis, or HIV. this usually back to normal 10–14 days.



Aspartate transaminase (AST) This was the first used.is not specific for heart damage, and it is also one of the liver function tests.


Myoglobin (Mb) low specificity for myocardial infarction 2 hours Myoglobin is used less than the other markers. Myoglobin is the primary oxygen-carrying pigment of muscle tissue. It is high when muscle tissue is damaged but it lacks specificity. It has the advantage of responding very rapidly, rising and falling earlier than CK-MB or troponin. It also has been used in assessing reperfusion after thrombolysis.



Ischemia-modified albumin (IMA) low specificity IMA can be detected via the albumin cobalt binding (ACB) test, a limited available FDA approved assay. Myocardial ischemia alters the N-terminus of albumin reducing the ability of cobalt to bind to albumin. IMA measures ischemia in the blood vessels and thus returns results in minutes rather than traditional markers of necrosis that take hours. ACB test has low specificity therefore generating high number of false positives and must be used in conjunction with typical acute approaches such as ECG and physical exam. Additional studies are required.



Pro-brain natriuretic peptide This is increased in patients with heart failure. It has been approved as a marker for acute congestive heart failure. Pt with < 80 have a much higher rate of symptom free survival within a year. Generally, pt with CHF will have > 100.


Glycogen phosphorylase isoenzyme BB high sensitivity and specificity early after chest pain 7 hours


Glycogen phosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogen phosphorylase. Glycogen phosphorylase exists in 3 isoforms. One of these Isoforms is GP-BB. This isoform exists in heart and brain tissue. Because of the blood-brain barrier GP-BB can be seen as heart muscle specific. During the process of ischemia, GP-BB is converted into a soluble form and is released into the blood. This isoform of the enzyme exists in cardiac (heart) and brain tissue. GP-BB is one of the "new cardiac markers" which are discussed to improve early diagnosis in acute coronary syndrome. A rapid rise in blood levels can be seen in myocardial infarction and unstable angina. GP-BB elevated 1–3 hours after process of ischemia.




Recently, the intentional destruction of myocardium by alcohol septal ablation has led to the identification of additional potential markers.



Limitations

Depending on the marker, it can take between 2 to 24 hours for the level to increase in the blood. Additionally, determining the levels of cardiac markers in the laboratory - like many other lab measurements - takes substantial time. Cardiac markers are therefore not useful in diagnosing a myocardial infarction in the acute phase. The clinical presentation and results from an ECG are more appropriate in the acute situation.


However, in 2010, research at the Baylor College of Medicine revealed that, using diagnostic nanochips and a swab of the cheek, cardiac biomarker readings from saliva can, with the ECG readings, determine within minutes whether someone is likely to have had a heart attack.


Further reading

Cardiac Intensive Care: Expert Consult: Online and Print (Expert Consult Title: Online + Print)Cardiovascular Critical Care


 Davis's Comprehensive Handbook of Laboratory and Diagnostic Tests With Nursing Implications (Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests With Nursing Implications)Nursing Implications of Lab Tests (A Wiley medical publication)


Ross G, Bever F, Uddin Z, Devireddy L, Gardin J (2004). "Common scenarios to clarify the interpretation of cardiac markers". J Am Osteopath Assoc 104

www.magnabiosciences.com/cardiacMarkers.html

https://www.aarphealthcare.com/galecontent/cardiac-marker-tests